(Selected for liver cancer research or genomic approaches for cancer research, published by PIs (bold-face) of this proposal)


1. Malogolowkin MH, Katzenstein HM, Meyers RL, Krailo MD, Rowland JM, Haas J, Finegold MJ, Complete Surgical Resection Is Curative for Children With Hepatoblastoma With Pure Fetal Histology: A Report From the Children's Oncology Group., J Clin Oncol. 2011 Aug 20;29(24):3301-6. Epub 2011 Jul 18, [ 21768450 ]
2. Litten J, Chen T, Schultz R, Schiffman J, Hermann K, Tomlinson G, Rakheja D., Activated NOTCH2 is overexpressed in hepatoblastomas: an immunohistochemical study., Pediatr Dev Pathol. 2011 Jun 3. [Epub ahead of print], [ 21639801 ]
3. Hadzic N, Finegold MJ, Liver neoplasia in children, Clin Liver Dis. 2011 May;15(2):443-62, vii-x., [ 21689623 ]
4. Joshi AD, Parsons DW, Velculescu VE, Riggins GJ., Sodium ion channel mutations in glioblastoma patients correlate with shorter survival., Mol Cancer. 2011 Feb 11;10:17., [ 21314958 ]
5. Parsons DW, Li M, Zhang X, Jones S, Leary RJ, Lin JC, Boca SM, Carter H, Samayoa J, Bettegowda C, Gallia GL, Jallo GI, Binder ZA, Nikolsky Y, Hartigan J, Smith DR, Gerhard DS, Fults DW, VandenBerg S, Berger MS, Marie SK, Shinjo SM, et al., The genetic landscape of the childhood cancer medulloblastoma., Science. 2011 Jan 28;331(6016):435-9. Epub 2010 Dec 16., [ 21163964 ]
6. Lopez-Terrada D , Molecular Diagnostic Testing in Solid Tumors, Arch Pathol Lab Med. 2011 Jan;135(1):67-82, [ 21204713 ]
7. Roy A, Finegold MJ , Hepatic neoplasia and metabolic diseases in children, Clin Liver Dis. 2010 Nov;14(4):731-46, [ 21055693 ]
8. Parsons DW., The evolving picture of the glioblastoma genome., Oncotarget. 2010 Aug;1(4):237-8. No abstract available. , [ 21304175 ]
9. Reitman ZJ, Parsons DW, Yan H., IDH1 and IDH2: not your typical oncogenes., Cancer Cell. 2010 Mar 16;17(3):215-6., [ 20227034 ]
10. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL, Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver, Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1437-42. Epub 2010 Jan 4, [ 20080689 ]
11. Katzenstein HM, Chang KW, Krailo M, Chen Z, Finegold MJ, Rowland J, Reynolds M, Pappo A, London WB, Malogolowkin M; Children's Oncology Group, Amifostine does not prevent platinum-induced hearing loss associated with the treatment of children with hepatoblastoma: a report of the Intergroup Hepatoblastoma Study P9645 as a part of the Children's Oncology Group., Cancer. 2009 Dec 15;115(24):5828-35, [ 19813275 ]
12. Yan H, Bigner DD, Velculescu V, Parsons DW., Mutant metabolic enzymes are at the origin of gliomas., Cancer Res. 2009 Dec 15;69(24):9157-9. Epub . Review., [ 19996293 ]
13. Chen TT, Rakheja D, Hung JY, Hornsby PJ, Tabaczewski P, Malogolowkin M, Feusner J, Miskevich F, Schultz R, Tomlinson GE , Establishment and characterization of a cancer cell line derived from an aggressive childhood liver tumor, Pediatr Blood Cancer. 2009 Dec;53(6):1040-7, [ 19637320 ]
14. Ji J, Shi J, Budhu A, Yu Z, Forgues M, Roessler S, Ambs S, Chen Y, Meltzer PS, Croce CM, Qin LX, Man K, Lo CM, Lee J, Ng IO, Fan J, Tang ZY, Sun HC, Wang XW, MicroRNA expression, survival, and response to interferon in liver cancer., N Engl J Med. 2009 Oct 8;361(15):1437-47., [ 19812400 ]
15. Lopez-Terrada D, Cheung SW, Finegold MJ, Knowles BB, Hep G2 is a hepatoblastoma-derived cell line, Hum Pathol. 2009 Oct;40(10):1512-5, [ 19751877 ]
16. Holdhoff M, Parsons DW, Diaz LA Jr., Mutations of IDH1 and IDH2 are not detected in brain metastases of colorectal cancer., J Neurooncol. 2009 Sep;94(2):297. Epub 2009 Apr 7. No abstract available. , [ 19350208 ]
17. Blackford A, Serrano OK, Wolfgang CL, Parmigiani G, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Cameron JL, Olino K, Schulick R, Winter J, Herman JM, Laheru D, Klein AP, Vogelstein B, et al., SMAD4 gene mutations are associated with poor prognosis in pancreatic cancer., Clin Cancer Res. 2009 Jul 15;15(14):4674-9. Epub 2009 Jul 7., [ 19584151 ]
18. Lopez-Terrada D, Gunaratne PH, Adesina AM, Pulliam J, Hoang DM, Nguyen Y, Mistretta TA, Margolin J, Finegold MJ , Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors, Hum Pathol. 2009 Jun;40(6):783-94. Epub 2009 Feb 5, [ 19200579 ]
19. Adesina AM, Lopez-Terrada D, Wong KK, Gunaratne P, Nguyen Y, Pulliam J, Margolin J, Finegold MJ , Gene expression profiling reveals signatures characterizing histologic subtypes of hepatoblastoma and global deregulation in cell growth and survival pathways, Hum Pathol. 2009 Jun;40(6):843-53. Epub 2009 Feb 5, [ 19200578 ]
20. Blackford A, Parmigiani G, Kensler TW, Wolfgang C, Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Eshleman JR, Goggins M, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Klein A, Cameron JL, Olino K, Schulick R, Winter J, Vogelstein B, Velculescu VE, Kinzler KW, et al., Genetic mutations associated with cigarette smoking in pancreatic cancer., Cancer Res. 2009 Apr 15;69(8):3681-8. Epub 2009 Apr 7., [ 19351817 ]
21. Jones S, Hruban RH, Kamiyama M, Borges M, Zhang X, Parsons DW, Lin JC, Palmisano E, Brune K, Jaffee EM, Iacobuzio-Donahue CA, Maitra A, Parmigiani G, Kern SE, Velculescu VE, Kinzler KW, Vogelstein B, Eshleman JR, Goggins M, Klein AP., Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene., Science. 2009 Apr 10;324(5924):217. Epub 2009 Mar 5., [ 19264984 ]
22. Trobaugh-Lotrario AD, Tomlinson GE, Finegold MJ, Gore L, Feusner JH, Small cell undifferentiated variant of hepatoblastoma: adverse clinical and molecular features similar to rhabdoid tumors, Pediatr Blood Cancer. 2009 Mar;52(3):328-34, [ 18985717 ]
23. Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD., IDH1 and IDH2 mutations in gliomas., N Engl J Med. 2009 Feb 19;360(8):765-73., [ 19228619 ]
24. Baillargeon J, Snyder N, Soloway RD, Paar D, Baillargeon G, Spaulding AC, Pollock BH, Arcari CM, Williams BA, Raimer BG., Hepatocellular carcinoma prevalence and mortality in a male state prison population., Public Health Rep. 2009 Jan-Feb;124(1):120-6., [ 19413034 ]
25. Finegold MJ, Egler RA, Goss JA, Guillerman RP, Karpen SJ, Krishnamurthy R, O'Mahony CA, Liver tumors: pediatric population, Liver Transpl. 2008 Nov;14(11):1545-56, [ 18975283 ]
26. Leary RJ, Lin JC, Cummins J, Boca S, Wood LD, Parsons DW, Jones S, Sj_blom T, Park BH, Parsons R, Willis J, Dawson D, Willson JK, Nikolskaya T, Nikolsky Y, Kopelovich L, Papadopoulos N, Pennacchio LA, Wang TL, Markowitz SD, Parmigiani G, Kinzler KW, et al., Integrated analysis of homozygous deletions, focal amplifications, and sequence alterations in breast and colorectal cancers., Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16224-9. Epub 2008 Oct 13., [ 18852474 ]
27. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Kamiyama H, Jimeno A, Hong SM, Fu B, Lin MT, Calhoun ES, Kamiyama M, Walter K, Nikolskaya T, Nikolsky Y, Hartigan J, Smith DR, Hidalgo M, Leach SD, et al., Core signaling pathways in human pancreatic cancers revealed by global genomic analyses., Science. 2008 Sep 26;321(5897):1801-6. Epub 2008 Sep 4., [ 18772397 ]
28. Parsons DW, Jones S, Zhang X, Lin JC, Leary RJ, Angenendt P, Mankoo P, Carter H, Siu IM, Gallia GL, Olivi A, McLendon R, Rasheed BA, Keir S, Nikolskaya T, Nikolsky Y, Busam DA, Tekleab H, Diaz LA Jr, Hartigan J, Smith DR, Strausberg RL, et al., An integrated genomic analysis of human glioblastoma multiforme., Science. 2008 Sep 26;321(5897):1807-12. Epub 2008 Sep 4., [ 18772396 ]
29. Litten JB, Tomlinson GE., Liver tumors in children., Oncologist. 2008 Jul;13(7):812-20. Epub 2008 Jul 21. Review., [ 18644850 ]
30. Segal NH, Parsons DW, Peggs KS, Velculescu V, Kinzler KW, Vogelstein B, Allison JP., Epitope landscape in breast and colorectal cancer., Cancer Res. 2008 Feb 1;68(3):889-92., [ 18245491 ]
31. Wood LD, Parsons DW, Jones S, Lin J, Sj_blom T, Leary RJ, Shen D, Boca SM, Barber T, Ptak J, Silliman N, Szabo S, Dezso Z, Ustyanksky V, Nikolskaya T, Nikolsky Y, Karchin R, Wilson PA, Kaminker JS, Zhang Z, Croshaw R, Willis J, et al., The genomic landscapes of human breast and colorectal cancers., Science. 2007 Nov 16;318(5853):1108-13. Epub 2007 Oct 11., [ 17932254 ]
32. Lin J, Gan CM, Zhang X, Jones S, Sj_blom T, Wood LD, Parsons DW, Papadopoulos N, Kinzler KW, Vogelstein B, Parmigiani G, Velculescu VE., A multidimensional analysis of genes mutated in breast and colorectal cancers., Genome Res. 2007 Sep;17(9):1304-18. Epub 2007 Aug 10., [ 17693572 ]
33. Budhu A,Chen Y, Kim JW, Forgues M, Valerie K, Harris CC, Wang XW, Induction of a unique gene expression profile in primary human hepatocytes by hepatitis C virus core, NS3 and NS5A proteins., Carcinogenesis. 2007 Jul;28(7):1552-60. Epub 2007 Apr 2., [ 17404395 ]
34. Adesina AM, Nguyen Y, Guanaratne P, Pulliam J, Lopez-Terrada D, Margolin J, Finegold M, FOXG1 is overexpressed in hepatoblastoma, Hum Pathol. 2007 Mar;38(3):400-9. Epub 2007 Jan 10, [ 17217994 ]
35. Jia HL, Ye QH, Qin LX, Budhu A, Forgues M, Chen Y, Liu YK, Sun HC, Wang L, Lu HZ, Shen F, Tang ZY, Wang XW, Gene expression profiling reveals potential biomarkers of human hepatocellular carcinoma., Clin Cancer Res. 2007 Feb 15;13(4):1133-9., [ 17317821 ]
36. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, et al., The consensus coding sequences of human breast and colorectal cancers., Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7., [ 16959974 ]
37. Budhu A, Forgues M, Ye QH, Jia HL, He P, Zanetti KA, Kammula US,Chen Y, Qin LX, Tang ZY, Wang XW, Prediction of venous metastases, recurrence, and prognosis in hepatocellular carcinoma based on a unique immune response signature of the liver microenvironment., Cancer Cell. 2006 Aug;10(2):99-111., [ 16904609 ]
38. Malogolowkin MH, Katzenstein H, Krailo MD, Chen Z, Bowman L, Reynolds M, Finegold M, Greffe B, Rowland J, Newman K, Womer RB, London WB, Castleberry RP, Intensified platinum therapy is an ineffective strategy for improving outcome in pediatric patients with advanced hepatoblastoma, J Clin Oncol. 2006 Jun 20;24(18):2879-84, [ 16782927 ]
39. Lopez-Terrada D , Integrating the diagnosis of childhood malignancies, Adv Exp Med Biol. 2006;587:121-37, [ 17163162 ]
40. Koldej R, Cmielewski P, Stocker A, Parsons DW, Anson DS., Optimisation of a multipartite human immunodeficiency virus based vector system; control of virus infectivity and large-scale production., J Gene Med. 2005 Nov;7(11):1390-9., [ 16025547 ]
41. Tomlinson GE, Douglass EC, Pollock BH, Finegold MJ, Schneider NR, Cytogenetic evaluation of a large series of hepatoblastomas: numerical abnormalities with recurring aberrations involving 1q12-q21, Genes Chromosomes Cancer 44:177-84, 2005, [ 15981236 ]
42. Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE., Colorectal cancer: mutations in a signalling pathway., Nature. 2005 Aug 11;436(7052):792., [ 16094359 ]
43. Hirschman BA, Pollock BH, Tomlinson GE, The spectrum of APC mutations in children with hepatoblastoma from familial adenomatous polyposis kindreds, J Pediatr. 2005 Aug;147(2):263-6, [ 16126064 ]
44. Parsons DW., Airway gene therapy and cystic fibrosis., J Paediatr Child Health. 2005 Mar;41(3):94-6. Review., [ 15790317 ]
45. Rakheja D, Margraf LR, Tomlinson GE, Schneider NR., Hepatic mesenchymal hamartoma with translocation involving chromosome band 19q13.4: a recurrent abnormality., Cancer Genet Cytogenet. 2004 Aug;153(1):60-3. Review., [ 15325096 ]
46. Pakakasama S, Chen TT, Frawley W, Muller CY, Douglass EC, Lee R, Pollock BH, Tomlinson GE, CCND1 polymorphism and age of onset of hepatoblastoma, Oncogene. 2004 Jun 10;23(27):4789-92, [ 15133490 ]
47. Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE., Mutational analysis of the tyrosine phosphatome in colorectal cancers., Science. 2004 May 21;304(5674):1164-6., [ 15155950 ]
48. Wang Z, Cummins JM, Shen D, Cahill DP, Jallepalli PV, Wang TL, Parsons DW, Traverso G, Awad M, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz SD, Goldberg ML, Karess R, Kinzler KW, Vogelstein B, Velculescu VE, Lengauer C., Three classes of genes mutated in colorectal cancers with chromosomal instability., Cancer Res. 2004 May 1;64(9):2998-3001., [ 15126332 ]
49. Baillargeon J, Kelley MF, Leach CT, Baillargeon G, Pollock BH., Methicillin-resistant Staphylococcus aureus infection in the Texas prison system., Clin Infect Dis. 2004 May 1;38(9):e92-5. Epub 2004 Apr 14., [ 15127360 ]
50. Kennedy JD, Blunden S, Hirte C, Parsons DW, Martin AJ, Crowe E, Williams D, Pamula Y, Lushington K., Reduced neurocognition in children who snore., Pediatr Pulmonol. 2004 Apr;37(4):330-7., [ 15022130 ]
51. Kim JW, Ye Q, Forgues M, Chen Y, Budhu A, Sime J, Hofseth LJ, Kaul R, Wang XW, Cancer-associated molecular signature in the tissue samples of patients with cirrhosis., Hepatology. 2004 Feb;39(2):518-27., [ 14768006 ]
52. Pakakasama S, Chen TT, Frawley W, Muller C, Douglass EC, Tomlinson GE., Myeloperoxidase promotor polymorphism and risk of hepatoblastoma., Int J Cancer. 2003 Aug 20;106(2):205-7., [ 12800195 ]
53. Shekhawat P, Bennett MJ, Sadovsky Y, Nelson DM, Rakheja D, Strauss AW., Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases., Am J Physiol Endocrinol Metab. 2003 Jun;284(6):E1098-105. Epub 2003 Feb 11., [ 12582009 ]
54. Pollock BH, Jenson HB, Leach CT, McClain KL, Hutchison RE, Garzarella L, Joshi VV, Parmley RT, Murphy SB., Risk factors for pediatric human immunodeficiency virus-related malignancy., JAMA. 2003 May 14;289(18):2393-9., [ 12746363 ]
55. Comerford SA, Clouthier DE, Hinnant EA, Hammer RE., Induction of hepatocyte proliferation and death by modulation of T-Antigen expression., Oncogene. 2003 Apr 24;22(16):2515-30., [ 12717428 ]
56. Ye QH, Qin LX, Forgues M, He P, Kim JW, Peng AC, Simon R, Li Y, Robles AI, Chen Y, Ma ZC, Wu ZQ, Ye SL, Liu YK, Tang ZY, Wang XW, Predicting hepatitis B virus-positive metastatic hepatocellular carcinomas using gene expression profiling and supervised machine learning., Nat Med. 2003 Apr;9(4):416-23. Epub 2003 Mar 17., [ 12640447 ]
57. Pakakasama S, Tomlinson GE., Genetic predisposition and screening in pediatric cancer., Pediatr Clin North Am. 2002 Dec;49(6):1393-413. Review., [ 12580371 ]
58. Katzenstein HM, Krailo MD, Malogolowkin MH, Ortega JA, Liu-Mares W, Douglass EC, Feusner JH, Reynolds M, Quinn JJ, Newman K, Finegold MJ, Haas JE, Sensel MG, Castleberry RP, Bowman LC, Hepatocellular carcinoma in children and adolescents: results from the Pediatric Oncology Group and the Children's Cancer Group intergroup study, J Clin Oncol. 2002 Jun 15;20(12):2789-97, [ 12065555 ]
59. Rakheja D, Bennett MJ, Rogers BB., Long-chain L-3-hydroxyacyl-coenzyme a dehydrogenase deficiency: a molecular and biochemical review., Lab Invest. 2002 Jul;82(7):815-24. Review., [ 12118083 ]
60. Haas JE, Feusner JH, Finegold MJ, Small cell undifferentiated histology in hepatoblastoma may be unfavorable, Cancer, 2001 Dec 15;92(12):3130-4, [ 11753992 ]
61. Ortega JA, Douglass EC, Feusner JH, Reynolds M, Quinn JJ, Finegold MJ, Haas JE, King DR, Liu-Mares W, Sensel MG, Krailo MD, Randomized comparison of cisplatin/vincristine/fluorouracil and cisplatin/continuous infusion doxorubicin for treatment of pediatric hepatoblastoma: A report from the Children?s Cancer Group and The Pediatric Oncology Group, J Clin Oncol. 2000 Jul;18(14):2665-75, [ 10894865 ]
62. Ross JA, Severson RK, Swensen AR, Pollock BH, Gurney JG, Robison LL., Seasonal variations in the diagnosis of childhood cancer in the United States., Br J Cancer. 1999 Oct;81(3):549-53., [ 10507784 ]
63. Clouthier DE, Comerford SA, Hammer RE., Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice., J Clin Invest. 1997 Dec 1;100(11):2697-713., [ 9389733 ]
64. Schneider NR, Cooley LD, Finegold MJ, Douglass EC, Tomlinson GE , The First Recurring Chromosome Translocation in Hepatoblastoma: der(4)t(1;4)(q12;q34), Genes Chromosomes Cancer. 1997 Aug;19(4):291-4, [ 9258666 ]
65. Finegold MJ , Tumor of the Liver, Semin Liver Dis. 1994 Aug;14(3):270-81, [ 7939787 ]
66. Douglass EC, Reynolds M, Finegold M, Cantor AB, Glicksman A, Cisplatin, vincristine, and fluorouracil therapy for hepatoblastoma: a Pediatric Oncology Group study, J Clin Oncol. 1993 Jan;11(1):96-9, [ 8380296 ]
67. Reynolds M, Douglass EC, Finegold M, Cantor A, Glicksman A, Chemotherapy can convert unresectable hepatoblastoma, J Pediatr Surg. 1992 Aug;27(8):1080-3; discussion 1083-4, [ 1328586 ]
68. Lee TH, Finegold MJ, Shen RF, DeMayo JL, Woo SL, Butel JS, Hepatitis B Virus Transactivator X Protein is not Tumorigenic in Transgenic Mice, J Virol. 1990 Dec;64(12):5939-47, [ 2243380 ]
69. Garber JE, Li FP, Kingston JE, Krush AJ, Strong LC, Finegold MJ, Bertario L, Bulow S, Filippone A Jr, Gedde-Dahl T Jr, et al., Hepatoblastoma and familial adenomatous polyposis, J Natl Cancer Inst. 1988 Dec 21;80(20):1626-8, [ 2848134 ]
70. Weinberg AG, Finegold MJ, Primary hepatic tumors of childhood, Hum Pathol. 1983 Jun;14(6):512-37, [ 6303939 ]